This may nor may not be related to the (immensely annoying!) pixel alignment issue.

Example Picture

In full screen there is no problem, but in the standard size view, this blurred imagery is really unsightly. Moving things around and messing with them in the editor can change graphics from being clean, sharp and great looking to blurry messes which just don't fit with the rest of the visuals.

Can anyone enlighten me about this further?

I do not know what causes this.